Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.

  title={Amyloid beta-induced neuronal death is bax-dependent but caspase-independent.},
  author={Larry Selznick and Timothy S. Zheng and Richard A Flavell and Pasko Raki{\'c} and Kevin A. Roth},
  journal={Journal of neuropathology and experimental neurology},
  volume={59 4},
Fibrillar amyloid beta (Abeta) peptides are major constituents of senile plaques in Alzheimer disease (AD) brain and cause neuronal apoptosis in vitro. Bax and caspase-3 have been implicated in the pathogenesis of AD and are components of a well-defined molecular pathway of neuronal apoptosis. To determine whether Abeta-induced neuronal apoptosis involves bax and/or caspase-3 activation, we examined the effect of Abeta on wild-type, bax-deficient, and caspase-3-deficient telencephalic neurons… CONTINUE READING
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