Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease.

  title={Amyloid beta-induced nerve growth factor dysmetabolism in Alzheimer disease.},
  author={Martin A. Bruno and Wanda Carolina Leon and Gabriela Fragoso and Walter E. Mushynski and Guillermina Almazan and Augusto Claudio Cuello},
  journal={Journal of neuropathology and experimental neurology},
  volume={68 8},
We previously reported that the precursor form of nerve growth factor (pro-NGF) and not mature NGF is liberated in the CNS in an activity-dependent manner, and that its maturation and degradation occur in the extracellular space by the coordinated action of proteases.Here, we present evidence of diminished conversion of pro-NGF to its mature form and of greater NGF degradation in Alzheimer disease (AD) brain samples compared with controls. These alterations of the NGF metabolic pathway likely… CONTINUE READING
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Beta-amyloidYmediated inhibition of NMDA receptorYdependent long-term potentiation induction involves Bruno et al

  • Q Wang, MJ Rowan, R. Anwyl
  • J Neuropathol Exp Neurol Volume 68,
  • 2009

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