Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans.

@article{Lemere2006AmyloidbetaIF,
  title={Amyloid-beta immunotherapy for the prevention and treatment of Alzheimer disease: lessons from mice, monkeys, and humans.},
  author={Cynthia A Lemere and Marcel Maier and Liying Jiang and Ying Hua Peng and Timothy J. Seabrook},
  journal={Rejuvenation research},
  year={2006},
  volume={9 1},
  pages={
          77-84
        }
}
Alzheimer disease (AD), the most common form of dementia, is without an effective cure or preventive treatment. Recently, amyloid-beta protein (Abeta) has become a major therapeutic target. Many efforts are underway to either reduce the production of Abeta or enhance its clearance. In 1999, Schenk and colleagues first showed that active immunization with full-length Abeta lowered cerebral Abeta levels in transgenic mice. These findings have been confirmed and extended in various transgenic… CONTINUE READING
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