Amyloid beta from axons and dendrites reduces local spine number and plasticity

  title={Amyloid beta from axons and dendrites reduces local spine number and plasticity},
  author={Wei Wei and Louis N. Nguyen and Helmut W Kessels and Hiroaki Hagiwara and Sangram S. Sisodia and Roberto Malinow},
  journal={Nature Neuroscience},
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease. Amyloid beta (Aβ), a peptide secreted in an activity-modulated manner by neurons, has been implicated in the pathogenesis of Alzheimer's disease by removing dendritic spines, sites of excitatory synaptic transmission. However, issues regarding the subcellular source of Aβ, as well as the mechanisms of its production and actions that lead to synaptic loss, remain poorly understood. In rat organotypic… CONTINUE READING
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