Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid.

@article{Golabek1995AmyloidBB,
  title={Amyloid beta binding proteins in vitro and in normal human cerebrospinal fluid.},
  author={Adam A. Golabek and Marcos A. Marques and M Lalowski and Thomas Wisniewski},
  journal={Neuroscience letters},
  year={1995},
  volume={191 1-2},
  pages={79-82}
}
A major neuropathological feature of Alzheimer's disease (AD) is the deposition of amyloid beta (A beta) in the form of senile plaques. The A beta peptide exists both in a beta-pleated sheet fibrillar form in amyloid deposits and as a normal soluble protein in biological fluids. Numerous proteins have been identified immunohistochemically to be associated with senile plaques, where A beta is the major constituent. Some of the latter have also been suggested to be carriers of the normal soluble… CONTINUE READING