Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.

@article{Lombardo2003AmyloidbetaAT,
  title={Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.},
  author={Julianne A. Lombardo and Edward Stern and Megan E McLellan and Stephen T. Kajdasz and Gregory A. Hickey and Brian J. Bacskai and Bradley T. Hyman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 34},
  pages={10879-83}
}
The accumulation of amyloid-beta into insoluble plaques is a characteristic feature of Alzheimer's disease. Neuronal morphology is distorted by plaques: rather than being essentially straight, they are substantially more curved than those in control tissue, their trajectories become altered, and they are frequently distended or swollen, presumably affecting synaptic transmission. Clearance of plaques by administration of antibodies to amyloid-beta is a promising therapeutic approach to the… CONTINUE READING
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