Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability.

Abstract

Amyloid-beta (Abeta) peptides play a key role in the pathogenesis of Alzheimer's disease and exert various toxic effects on neurons; however, relatively little is known about their influence on glial cells. Astrocytes play a pivotal role in brain homeostasis, contributing to the regulation of local energy metabolism and oxidative stress defense, two aspects… (More)
DOI: 10.1523/JNEUROSCI.5098-09.2010

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Cite this paper

@article{Allaman2010AmyloidbetaAC, title={Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability.}, author={Igor Allaman and Mathilde Gavillet and Mireille B{\'e}langer and Thierry Laroche and David Viertl and Hilal A Lashuel and Pierre J. Magistretti}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2010}, volume={30 9}, pages={3326-38} }