Amyloid-beta Alzheimer targets — protein processing, lipid rafts, and amyloid-beta pores

@inproceedings{Arbor2016AmyloidbetaAT,
  title={Amyloid-beta Alzheimer targets — protein processing, lipid rafts, and amyloid-beta pores},
  author={Sage Arbor and Mike Lafontaine and Medhane Cumbay},
  booktitle={The Yale journal of biology and medicine},
  year={2016}
}
Amyloid beta (Aβ), the hallmark of Alzheimer's Disease (AD), now appears to be deleterious in its low number aggregate form as opposed to the macroscopic Aβ fibers historically seen postmortem. While Alzheimer targets, such as the tau protein, amyloid precursor protein (APP) processing, and immune system activation continue to be investigated, the recent discovery that amyloid beta aggregates at lipid rafts and likely forms neurotoxic pores has led to a new paradigm regarding why past… CONTINUE READING

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