Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice.

@article{Supnet2006Amyloidbeta142IR,
  title={Amyloid-beta-(1-42) increases ryanodine receptor-3 expression and function in neurons of TgCRND8 mice.},
  author={Charlene Supnet and Jeff Grant and Hong Kong and David Westaway and Michael Mayne},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 50},
  pages={38440-7}
}
Disruption of intracellular calcium homeostasis precedes the neurodegeneration that occurs in Alzheimer disease (AD). Of the many neuronal calcium-regulating proteins, we focused on endoplasmic reticulum (ER)-resident ryanodine receptors (RyRs) because they are increased in the hippocampus of mice expressing mutant presenilin-1 and are associated with neurotoxicity. Others have observed that ryanodine binding is elevated in human postmortem hippocampal regions suggesting that RyR(s) are… CONTINUE READING
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