Amyloid beta: the alternate hypothesis.

  title={Amyloid beta: the alternate hypothesis.},
  author={Hyoung-Gon Lee and Xiongwei Zhu and Akihiko Nunomura and George Perry and Mark A. Smith},
  journal={Current Alzheimer research},
  volume={3 1},
Alzheimer disease (AD) is a devastating condition and patients, caregivers, clinicians, and scientists are eager to decipher the underlying disease mechanism and, thereafter, target this therapeutically. Most investigators studying the underlying cause of AD have focused on amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the predominant mechanism thought to be responsible for the disease. However, a number of caveats have led us to seriously question the validity of this… CONTINUE READING
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