Amyloid-b Deposition Is Associated with Decreased Hippocampal Glucose Metabolism and Spatial Memory Impairment in APP / PS 1 Mice

@inproceedings{Sadowski2004AmyloidbDI,
  title={Amyloid-b Deposition Is Associated with Decreased Hippocampal Glucose Metabolism and Spatial Memory Impairment in APP / PS 1 Mice},
  author={Marcin Sadowski and Joanna Pankiewicz and Henrieta Scholtzova and Ji Yang Yong and David Quartermain and Catrin H Jensen and Karen E Duff and Ralph A. Nixon and Rand J. Gruen and Thomas Wisniewski},
  year={2004}
}
In Alzheimer disease (AD) patients, early memory dysfunction is associated with glucose hypometabolism and neuronal loss in the hippocampus. Double transgenic (Tg) mice co-expressing the M146L presenilin 1 (PS1) and K670N/ M671L, the double ‘‘Swedish’’ amyloid precursor protein (APP) mutations, are a model of AD amyloid-b deposition (Ab) that exhibits earlier and more profound impairments of working memory and learning than single APP mutant mice. In this study we compared performance on… CONTINUE READING