Amyloid-associated depression: a prodromal depression of Alzheimer disease?

  title={Amyloid-associated depression: a prodromal depression of Alzheimer disease?},
  author={Xiaoyan Sun and David C. Steffens and Rhoda Au and Marshal F. Folstein and Paul Summergrad and Jacqueline Yee and Irwin H. Rosenberg and David Mkaya Mwamburi and Wei Qiao Qiu},
  journal={Archives of general psychiatry},
  volume={65 5},
CONTEXT A high ratio of plasma amyloid-beta peptide 40 (Abeta(40)) to Abeta(42), determined by both high Abeta(40) and low Abeta(42) levels, increases the risk of Alzheimer disease. In a previous study, we reported that depression is also associated with low plasma Abeta(42) levels in the elderly population. OBJECTIVE To characterize plasma Abeta(40):Abeta(42) ratio and cognitive function in elderly individuals with and without depression. DESIGN Cross-sectional study. SETTING Homecare… CONTINUE READING


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