Amyloid and amyloidosis.

@article{Breathnach1988AmyloidAA,
  title={Amyloid and amyloidosis.},
  author={Stephen M Breathnach},
  journal={Journal of the American Academy of Dermatology},
  year={1988},
  volume={18 1 Pt 1},
  pages={1-16}
}
Cutaneous lesions are present in up to 40% of patients with primary and myeloma-associated systemic amyloidosis and occur as a result of tissue deposition of immunoglobulin light chain material derived from a circulating paraprotein. The occurrence of waxy, purpuric mucocutaneous lesions provides a crucial early pointer to underlying occult plasma cell dyscrasia; the combination of the symptoms of the carpal tunnel syndrome, macroglossia, and specific mucocutaneous lesions is highly… CONTINUE READING
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