Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging

@inproceedings{MatasGuiu2016AmyloidPA,
  title={Amyloid Proteins and Their Role in Multiple Sclerosis. Considerations in the Use of Amyloid-PET Imaging},
  author={Jordi A Mat{\'i}as-Guiu and Celia Oreja-Guevara and M N Cabrera-Mart{\'i}n and Teresa Moreno-Ramos and J L Carreras and J Mat{\'i}as-Guiu},
  booktitle={Front. Neurol.},
  year={2016}
}
Thioflavin T derivatives are used in positron-emission tomography (PET) studies to detect amyloid protein deposits in patients with Alzheimer disease. These tracers bind extensively to white matter, which suggests that they may be useful in studies of multiple sclerosis (MS), and that proteins resulting from proteolytic processing of the amyloid precursor protein (APP) may contribute to MS. This article reviews data from both clinical and preclinical studies addressing the role of these… CONTINUE READING
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