Amyloid Precursor Protein Mutation Disrupts Reproductive Experience-Enhanced Normal Cognitive Development in a Mouse Model of Alzheimer's Disease

@article{Cui2013AmyloidPP,
  title={Amyloid Precursor Protein Mutation Disrupts Reproductive Experience-Enhanced Normal Cognitive Development in a Mouse Model of Alzheimer's Disease},
  author={Jie Cui and Balaji Jothishankar and Ping He and Matthias Staufenbiel and Yong Shen and Rena Li},
  journal={Molecular Neurobiology},
  year={2013},
  volume={49},
  pages={103-112}
}
Women experience dramatic changes in hormones, mood and cognition through different periods of their reproductive lives, particularly during pregnancy and giving birth. While limited human studies of early pregnancy and motherhood showed alteration of cognitive functions in later life, researches on rodents showed a persistent improvement of learning and memory performance in females with history of giving birth compared to virgin controls. Alzheimer's disease (AD), the most common dementia in… CONTINUE READING
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