Amyloid P-Peptide Impairs Ion-Motive ATPase Activities : Evidence for a Role in Loss of Neuronal Ca 2 + Homeostasis and Cell Death

@inproceedings{Robert2001AmyloidPI,
  title={Amyloid P-Peptide Impairs Ion-Motive ATPase Activities : Evidence for a Role in Loss of Neuronal Ca 2 + Homeostasis and Cell Death},
  author={Robert and J.. and Mark and Kenneth and John Hensley and D. Allan and Butterfield},
  year={2001}
}
The amyloid P-peptide (AP) that accumulates as insoluble plaques in the brain in Alzheimer’s disease can be directly neurotoxic and can increase neuronal vulnerability to excitotoxic insults. The mechanism of Ap toxicity is unclear but is believed to involve generation of reactive oxygen species (ROS) and loss of calcium homeostasis. We now report that exposure of cultured rat hippocampal neurons to Apl-40 or AP25-35 causes a selective reduction in Na+/ K+-ATPase activity which precedes loss of… CONTINUE READING