Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons.

Abstract

Amyloid-beta (Aβ) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease (AD). However, the loss of synapses and dysfunctions of neurotransmission are more directly tied to disease severity. The role of these lesions in the pathoetiological progression of the disease remains contested. Biochemical, cellular, molecular, and pathological… (More)
DOI: 10.3233/JAD-160612

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Cite this paper

@article{Rajmohan2017AmyloidBetaAP, title={Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons.}, author={R. Rajmohan and Pranitha Reddy}, journal={Journal of Alzheimer's disease : JAD}, year={2017}, volume={57 4}, pages={975-999} }