Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Abstract

In Alzheimer’s disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endothelial cells that underlie these… (More)
DOI: 10.1007/s12035-014-8740-7

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