Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

@article{Rumble1989AmyloidAP,
  title={Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.},
  author={B A Rumble and Robert W Retallack and Christin Hilbich and G E Simms and Gerhard Multhaup and Ralph N. Martins and Athel Hockey and Patrick Montgomery and Konrad Beyreuther and Colin L. Masters},
  journal={The New England journal of medicine},
  year={1989},
  volume={320 22},
  pages={1446-52}
}
In patients with Alzheimer's disease, amyloid fibrils that are aggregates of A4 protein subunits are deposited in the brain. A similar process occurs at an earlier age in persons with Down's syndrome. To investigate the deposition of amyloid in these diseases, we used a radioimmunoassay to measure levels of the amyloid precursor (PreA4) in the serum of 17 patients with Down's syndrome, 15 patients with Alzheimer's disease, and 33 normal elderly controls. The mean (+/- SD) concentration of serum… CONTINUE READING
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