Amyloid-β42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis

@article{Vattemi2009Amyloid42IP,
  title={Amyloid-β42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis},
  author={G Vattemi and Anna Nogalska and W. King Engel and Carla D’Agostino and Fr{\'e}d{\'e}ric Checler and Valerie Askanas},
  journal={Acta Neuropathologica},
  year={2009},
  volume={117},
  pages={569-574}
}
Sporadic inclusion-body myositis (s-IBM) is the only muscle disease in which accumulation of amyloid-β (Aβ) in abnormal muscle fibers appears to play a key pathogenic role. Increased amyloid-β precursor protein (AβPP) and Aβ accumulation have been reported to be upstream steps in the development of the s-IBM pathologic phenotype, based on cellular and animal models. Aβ is released from AβPP as a 40 or 42 aminoacid peptide. Aβ42 is considered more cytotoxic than Aβ40, and it has a higher… CONTINUE READING

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