Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse.

@article{Varga2015Amyloid142DS,
  title={Amyloid-β1-42 Disrupts Synaptic Plasticity by Altering Glutamate Recycling at the Synapse.},
  author={Edina Varga and G{\'a}bor Juh{\'a}sz and Zsolt Bozsó and Botond Penke and L{\'i}via F{\"u}l{\"o}p and Viktor Szegedi},
  journal={Journal of Alzheimer's disease : JAD},
  year={2015},
  volume={45 2},
  pages={
          449-56
        }
}
Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorders characterized by neuritic plaques containing amyloid-β peptide (Aβ) and neurofibrillary tangles. Evidence has been reported that Aβ(1-42) plays an essential pathogenic role in decreased spine density, impairment of synaptic plasticity, and neuronal loss with disruption of memory-related synapse function, all associated with AD. Experimentally, Aβ(1-42) oligomers perturb hippocampal long-term potentiation (LTP… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Abeta ( 1398 42 ) Enhances Neuronal Excitability in the CA 1 via NR 2 B 399 SubunitContaining NMDA Receptors

E Varga, V Szegedi
  • Neural Plasticity
  • 2014

A foldamerdendrimer conjugate neutralizes synap335 totoxic betaamyloid oligomers

L Fulop, IM Mandity, +8 authors TA Martinek
  • PLoS One
  • 2012

Astrocytic adenosine A 2 A 388 receptors control the amyloidbeta peptideinduced decrease 389 of glutamate uptake

M Matos, E Augusto, +3 authors P Agostinho
  • J Alzheimers Dis
  • 2012