Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil


INTRODUCTION Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are toxic to synapses. We previously demonstrated that Aβ induces Dickkopf-1 (Dkk1), which in turn activates the Wnt-planar… (More)
DOI: 10.1016/j.jalz.2017.09.008


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