Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

@article{Shankar2008AmyloidPD,
  title={Amyloid-$\beta$ protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory},
  author={G. Shankar and Shaomin Li and Tapan Mehta and A. Garc{\'i}a-Mu{\~n}oz and Nina E. Shepardson and Imelda M. Smith and F. Brett and Michael A. Farrell and M. Rowan and C. Lemere and C. Regan and D. Walsh and B. Sabatini and D. Selkoe},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={837-842}
}
Alzheimer's disease constitutes a rising threat to public health. Despite extensive research in cellular and animal models, identifying the pathogenic agent present in the human brain and showing that it confers key features of Alzheimer's disease has not been achieved. We extracted soluble amyloid-β protein (Aβ) oligomers directly from the cerebral cortex of subjects with Alzheimer's disease. The oligomers potently inhibited long-term potentiation (LTP), enhanced long-term depression (LTD) and… Expand
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