Amyloid-β plaques disrupt axon initial segments.

@article{Marin2016AmyloidPD,
  title={Amyloid-β plaques disrupt axon initial segments.},
  author={Miguel A Marin and Jokubus Ziburkus and Joanna L. Jankowsky and Matthew N Rasband},
  journal={Experimental neurology},
  year={2016},
  volume={281},
  pages={93-8}
}
UNLABELLED Amyloid-β (Aβ) plaques are one of the central pathologies of Alzheimer's disease (AD). Plaque formation in animal models of AD coincides with the appearance of synaptic abnormalities, aberrant neuronal excitability, and cognitive decline. Aβ plaques may disrupt neuronal excitability since they have been proposed to be synaptotoxic, to induce axonal varicosities and neurite breakage, and to significantly decrease spine density. Axon initial segments (AIS) also regulate neuronal… CONTINUE READING
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