Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains.

  title={Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains.},
  author={Maria Carmela Nicastro and Dario Spigolon and Fabio Librizzi and Oscar Moran and Maria Grazia Ortore and Donatella Bulone and Pier Luigi San Biagio and Rita Carrotta},
  journal={Biophysical chemistry},
Neuronal membrane damage is related to the early impairments appearing in Alzheimer's disease due to the interaction of the amyloid β-peptide (Aβ) with the phospholipid bilayer. In particular, the ganglioside GM1, present with cholesterol in lipid rafts, seems to be able to initiate Aβ aggregation on membrane. We studied the thermodynamic and structural effects of the presence of GM1 on the interaction between Aβ and liposomes, a good membrane model system. Isothermal Titration Calorimetry… CONTINUE READING