Amyloid-β oligomers regulate the properties of human neural stem cells through GSK-3β signaling

  title={Amyloid-β oligomers regulate the properties of human neural stem cells through GSK-3β signaling},
  author={I Re Lee and Kwangsoo Jung and Il-Sun Kim and Kook In Park},
  booktitle={Experimental & Molecular Medicine},
Alzheimer’s disease (AD) is the most common cause of age-related dementia. The neuropathological hallmarks of AD include extracellular deposition of amyloid-β peptides and neurofibrillary tangles that lead to intracellular hyperphosphorylated tau in the brain. Soluble amyloid-β oligomers are the primary pathogenic factor leading to cognitive impairment in AD. Neural stem cells (NSCs) are able to self-renew and give rise to multiple neural cell lineages in both developing and adult central… CONTINUE READING
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Inhibition of GSK 3 betamediated BACE 1 expression reduces Alzheimerassociated phenotypes

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