Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase.

@article{Neniskyte2016AmyloidI,
  title={Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase.},
  author={Urte Neniskyte and Michael Fricker and Guy C Brown},
  journal={The international journal of biochemistry & cell biology},
  year={2016},
  volume={81 Pt B},
  pages={
          346-355
        }
}
Alzheimer's disease is characterized by brain plaques of amyloid beta and by neuronal loss, but it is unclear how amyloid beta causes neuronal loss and how to prevent this loss. We have previously shown that amyloid beta causes neuronal loss by inducing microglia to phagocytose neurons, and here we investigated whether protein kinase Cs and NADPH oxidase were involved in this. The loss of neurons induced by amyloid beta in co-cultures of primary glia and neurons was completely prevented by… CONTINUE READING

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