Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production.

@article{Wang2017AmyloidI,
  title={Amyloid β induces NLRP3 inflammasome activation in retinal pigment epithelial cells via NADPH oxidase- and mitochondria-dependent ROS production.},
  author={Ke Wang and Yong Yao and Xue Zhu and Kai Zhang and Fanfan Zhou and Ling Zhu},
  journal={Journal of biochemical and molecular toxicology},
  year={2017},
  volume={31 6}
}
Amyloid β (Aβ)-induced chronic inflammation is believed to be a key pathogenic process in early-stage age-related macular degeneration (AMD). Nucleotide oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation triggered by Aβ is responsible for retinal pigment epithelium (RPE) dysfunction in the onset of… CONTINUE READING