Amyloid β-induced death in neurons involves glial and neuronal hemichannels.

@article{Orellana2011AmyloidD,
  title={Amyloid β-induced death in neurons involves glial and neuronal hemichannels.},
  author={Juan Andr{\'e}s Orellana and Kenji F Shoji and Ver{\'o}nica Abudara and Pascal Ezan and Edwige Amigou and Pablo J S{\'a}ez and Jean X Jiang and Christian C. Naus and Juan C S{\'a}ez and Christian Giaume},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 13},
  pages={4962-77}
}
The mechanisms involved in Alzheimer's disease are not completely understood and how glial cells contribute to this neurodegenerative disease remains to be elucidated. Because inflammatory treatments and products released from activated microglia increase glial hemichannel activity, we investigated whether amyloid-β peptide (Aβ) could regulate these channels in glial cells and affect neuronal viability. Microglia, astrocytes, or neuronal cultures as well as acute hippocampal slices made from… CONTINUE READING

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