Amyloid-β increases metallo- and cysteine protease activities in human macrophages.

  title={Amyloid-β increases metallo- and cysteine protease activities in human macrophages.},
  author={Jos{\'e} Castellano and Lina Badimon and Vicenta Llorente-Cort{\'e}s},
  journal={Journal of vascular research},
  volume={51 1},
BACKGROUND/AIMS Amyloid-β (Aβ) plays a crucial role in the onset and progression of atherosclerosis. Macrophages are a source of matrix metalloproteinases (MMPs), cysteine proteases and transforming growth factor (TGF)-β1 in the vascular wall. The aims of this study were to analyze the capacity of Aβ peptide (1-40) (Aβ40), Aβ peptide (1-42) (Aβ42) and fibrillar Aβ42 (fAβ42) to modulate the expression and activity of MMP-9, MMP-2 and tissue inhibitor of MMP-1 (TIMP-1) in human monocyte-derived… CONTINUE READING


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