Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin

  title={Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin},
  author={Enrico Malito and Raymond E Hulse and W.-J. Tang},
  journal={Cellular and Molecular Life Sciences},
The accumulation of aggregates of amyloidogenic peptides is associated with numerous human diseases. One well studied example is the association between deposition of amyloid β (Aβ) and Alzheimer’s disease. Insulin degrading enzyme and neprilysin are involved in the clearance of Aβ, and presequence peptidase is suggested to play a role in the degradation of mitochondrial Aβ. Recent structural analyses reveal that these three peptidases contain a catalytic chamber (crypt) that selectively… CONTINUE READING
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