Amyloid-β and the failure to form mitochondrial cristae: a biomimetic study involving artificial membranes.

@article{Khalifat2012AmyloidAT,
  title={Amyloid-β and the failure to form mitochondrial cristae: a biomimetic study involving artificial membranes.},
  author={Nada Khalifat and Nicolas Puff and Mariam Dliaa and Miglena I Angelova},
  journal={Journal of Alzheimer's disease : JAD},
  year={2012},
  volume={28 1},
  pages={33-48}
}
Alzheimer's disease (AD) is a degenerative disease of the central nervous system which causes irreversible damage to neuron structure and function. The main hypothesis concerning the cause of AD is excessive accumulation of amyloid-β peptides (Aβ). There has recently been a surge in studies on neuronal morphological and functional pathologies related to Aβ-induced mitochondrial dysfunctions and morphological alternations. What is the relation between the accumulation of Aβ in mitochondria… CONTINUE READING