Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK

@inproceedings{Ritchie2017AmyloidAI,
  title={Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK},
  author={Diane L Ritchie and Peter Adlard and Alexander H. Peden and Suzanne Lowrie and Margaret Le Grice and Kimberley Burns and Rosemary J. Jackson and Helen M. Yull and Michael J. Keogh and Wei Ya Wei and Patrick F. Chinnery and Mark W Head and James W Ironside},
  booktitle={Acta Neuropathologica},
  year={2017}
}
Human-to-human transmission of Creutzfeldt–Jakob disease (CJD) has occurred through medical procedures resulting in iatrogenic CJD (iCJD). One of the commonest causes of iCJD was the use of human pituitary-derived growth hormone (hGH) to treat primary or secondary growth hormone deficiency. As part of a comprehensive tissue-based analysis of the largest cohort yet collected (35 cases) of UK hGH-iCJD cases, we describe the clinicopathological phenotype of hGH-iCJD in the UK. In the 33/35 hGH… CONTINUE READING
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