Amyloid-β Receptors: The Good, the Bad, and the Prion Protein*

  title={Amyloid-β Receptors: The Good, the Bad, and the Prion Protein*},
  author={Heledd H. Jarosz-Griffiths and Elizabeth Noble and Jo V. Rushworth and Nigel M Hooper},
  booktitle={The Journal of biological chemistry},
Several different receptor proteins have been identified that bind monomeric, oligomeric, or fibrillar forms of amyloid-β (Aβ). "Good" receptors internalize Aβ or promote its transcytosis out of the brain, whereas "bad" receptors bind oligomeric forms of Aβ that are largely responsible for the synapticloss, memory impairments, and neurotoxicity that underlie Alzheimer disease. The prion protein both removes Aβ from the brain and transduces the toxic actions of Aβ. The clustering of distinct… CONTINUE READING
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