Amyloid β‐proteins 1—40 and 1—42(43) in the soluble fraction of extra‐ and intracranial blood vessels

@article{Shinkai1995Amyloid1,
  title={Amyloid $\beta$‐proteins 1—40 and 1—42(43) in the soluble fraction of extra‐ and intracranial blood vessels},
  author={Yasuhisa Shinkai and Masahiro Yoshimura and Yuji Ito and Asano Odaka and Nobuhiro Suzuki and Katsuhiko Yanagisawa and Yasuo Ihara},
  journal={Annals of Neurology},
  year={1995},
  volume={38}
}
To investigate the process of amyloid β‐protein (Aβ) accumulation in cerebral amyloid angiopathy (CAA), the levels of Aβ were determined in the soluble fraction of extra‐ and intracranial blood vessels and leptomeninges obtained at autopsy. Two enzyme immunoassays were employed that are known to sensitively and specifically quantify two Aβ species, Aβ1–40 and 1–42(43). Aβ was detectable in the intracranial blood vessels and leptomeninges with the latter containing the highest levels, while it… 
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