Amyloid-β(1–42) Protofibrils Formed in Modified Artificial Cerebrospinal Fluid Bind and Activate Microglia

@article{Paranjape2012Amyloid142PF,
  title={Amyloid-β(1–42) Protofibrils Formed in Modified Artificial Cerebrospinal Fluid Bind and Activate Microglia},
  author={Geeta S. Paranjape and Shana E. Terrill and Lisa K. Gouwens and Benjamin M. Ruck and Michael R Nichols},
  journal={Journal of Neuroimmune Pharmacology},
  year={2012},
  volume={8},
  pages={312-322}
}
Soluble aggregated forms of amyloid-β protein (Aβ) have garnered significant attention recently for their role in Alzheimer’s disease (AD). Protofibrils are a subset of these soluble species and are considered intermediates in the aggregation pathway to mature Aβ fibrils. Biological studies have demonstrated that protofibrils exhibit both toxic and inflammatory activities. It is important in these in vitro studies to prepare protofibrils using solution conditions that are appropriate for… CONTINUE READING
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