Amyloid, the presenilins and Alzheimer's disease.

  title={Amyloid, the presenilins and Alzheimer's disease.},
  author={John S. Hardy},
  journal={Trends in neurosciences},
  volume={20 4},
Various mutations in the amyloid protein precursor and presenilin genes can lead to early onset, autosomal Alzheimer's disease. A series of mis-sense mutations (with one exception) in each of these genes has been shown to cause disease in a fully penetrant fashion. It has recently been shown, both in vivo and in model systems, that tissues expressing these mutations have increased production of amyloid (A beta) ending at residue 42. It has also recently been shown that this form of A beta is… CONTINUE READING
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