Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.

@article{Lopez2014AmyloidNA,
  title={Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.},
  author={Oscar L. Lopez and William E. Klunk and Chester A. Mathis and Rhaven L Coleman and Julie C. Price and James T. Becker and H J Aizenstein and Beth Snitz and Ann D. Cohen and Milos D. Ikonomovic and Eric McDade and Steven DeKosky and Lisa A. Weissfeld and Lewis H. Kuller},
  journal={Neurology},
  year={2014},
  volume={83 20},
  pages={1804-11}
}
OBJECTIVE To examine the association between brain structural changes and β-amyloid deposition, and incident dementia in 183 elderly subjects without dementia (mean age 85.5 years) 2 years later. METHODS Subjects had a brain structural MRI scan and a PET scan with (11)C-labeled Pittsburgh compound B (PiB) in 2009, and were evaluated clinically in 2011. RESULTS At baseline evaluation, of the 183 participants (146 cognitively normal [CN]); 37 mild cognitive impairment [MCI]), 139 (76%) were… CONTINUE READING
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