Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat

@article{Clementi2005AmylinGB,
  title={Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat},
  author={Giuseppe Clementi and Antonina Caruso and Vincenza Maria Catena Cutuli and Ernesto de Bernardis and A. Dal Prato and Matilde Amico-Roxas},
  journal={Experientia},
  year={2005},
  volume={52},
  pages={677-679}
}
The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined. Amylin administered intracerebroventricularly (1, 2, 2.5 or 4 μg/rat) produced the maximal decrease in gastric emptying and intestinal transit at the dose of 2.5 μg/rat. Higher doses produced a lower effect. Peripheral administration (25, 50 or 100 μg/kg) produced dose-dependent effects. Pre-treatment with neostigmine blocked the effect of amylin when it was centrally injected, while the effect of… 
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Experimental diabetes impairs the ileal brake mechanism and disturbs gastric emptying, which may contribute to difficult glycaemic control.
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Support is provided for the hypothesis that IAPP is a satiety hormone which acts primarily in the brain to inhibit food intake and the mechanisms through which IAPP exerts its effects were investigated.
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  • T. Lutz
  • Biology
    Cellular and Molecular Life Sciences
  • 2011
TLDR
A series of recent experiments in animals and humans indicate that amylin is a promising option for anti-obesity therapy especially in combination with other hormones.
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