Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C2C12 muscle and AML12 liver cell lines

@article{Moon2011AmylinAL,
  title={Amylin and leptin activate overlapping signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C2C12 muscle and AML12 liver cell lines},
  author={H.-S. Moon and John P Chamberland and Christos S. Mantzoros},
  journal={Diabetologia},
  year={2011},
  volume={55},
  pages={215-225}
}
Aims/hypothesisIt has been suggested that amylin amplifies leptin’s effects and affects energy homeostasis synergistically with leptin in animals and humans. However, no previous study has reported on amylin and leptin signalling in hypothalamic, muscle and liver cells.MethodsLeptin and amylin signalling studies were performed in vitro in mouse GT1-7 hypothalamic, C2C12 muscle and AML12 liver cell lines.ResultsTreatment of mouse GT1-7 and C2C12 cells with leptin or amylin increased signal… CONTINUE READING

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