Amylin/leptin synergy is absent in extreme obesity and not restored by calorie restriction‐induced weight loss in rats

@inproceedings{Trevaskis2016AmylinleptinSI,
  title={Amylin/leptin synergy is absent in extreme obesity and not restored by calorie restriction‐induced weight loss in rats},
  author={James L Trevaskis and Carrie R. Wittmer and Jennifer R Athanacio and Peter S. Griffin and David G. Parkes and Jonathan David Roth},
  booktitle={Obesity science & practice},
  year={2016}
}
OBJECTIVE Co-administration of amylin and leptin induces synergistic and clinically meaningful (>10%) weight loss that is attenuated as the degree of obesity increases. We explored whether calorie restriction (CR) could restore amylin/leptin synergy in very obese rats. METHODS Sprague Dawley rats on high-fat diet (696 ± 8 g, n = 72) were randomized to three cohorts (C1-C3). Rats in C1 were administered vehicle, rat amylin (50 µg kg-1 d-1), murine leptin (125 µg kg-1 d-1) or amylin and leptin… CONTINUE READING
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