Amygdaloid kindling is anxiogenic but fails to alter object recognition or spatial working memory in rats

@article{Hannesson2008AmygdaloidKI,
  title={Amygdaloid kindling is anxiogenic but fails to alter object recognition or spatial working memory in rats},
  author={Darren K. Hannesson and M Pollock and John G. Howland and Paul Mohapel and A E Wallace and Michael E. Corcoran},
  journal={Epilepsy \& Behavior},
  year={2008},
  volume={13},
  pages={52-61}
}
Kindling in rats produces enduring behavioral changes that parallel the psychobehavioral disturbances frequently accompanying temporal lobe epilepsy. Some evidence suggests that the site of kindling is an important determinant of the type of behavioral changes observed following kindling, although this variable has not been systematically investigated. In the present experiments, the effects of amygdaloid kindling were assessed on a battery of behavioral tests we used previously to assess the… Expand
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TLDR
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TLDR
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Cortical kindling induces elevated levels of AMPA and GABA receptor subunit mRNA within the amygdala/piriform region and is associated with behavioral changes in the rat
TLDR
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Behavioral and Neurochemical Consequences of Pentylenetetrazol-Induced Kindling in Young and Middle-Aged Rats
TLDR
Findings reveal that, despite age-related differences during epileptogenesis, middle-aged rats evaluated after kindling performed similarly during discriminative learning and emotional tasks in comparison to young animals, with no alteration of hippocampal MAPKs. Expand
The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant activity amongst VTA dopamine neurons in both familiar and novel space
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PTZ kindling impairs novelty‐driven more than fear‐driven exploration, and reduced exploratory drive after kindling co‐varies with poorer spatial memory, which helps understand the aetiology of complex behavioural changes in the PTZkindling model, and may assist in the development of superior diagnoses and treatments for epilepsy. Expand
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