Amygdalar peptidergic circuits regulating noradrenergic locus coeruleus neurons: linking limbic and arousal centers.

@article{Reyes2011AmygdalarPC,
  title={Amygdalar peptidergic circuits regulating noradrenergic locus coeruleus neurons: linking limbic and arousal centers.},
  author={Beverly A. S. Reyes and Ana Franky Carvalho and Kunal Vakharia and Elisabeth J. Van Bockstaele},
  journal={Experimental neurology},
  year={2011},
  volume={230 1},
  pages={96-105}
}
The endogenous opioid peptides, met- or leu-enkephalin, and corticotropin-releasing factor (CRF) regulate noradrenergic neurons in the locus coeruleus (LC) in a convergent manner via projections from distinct brain areas. In contrast, the opioid peptide dynorphin (DYN) has been shown to serve as a co-transmitter with CRF in afferents to the LC. To further define anatomical substrates targeting noradrenergic neurons by DYN afferents originating from limbic sources, anterograde tract-tracing of… CONTINUE READING
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