Amygdala to nucleus accumbens excitatory transmission facilitates reward seeking

  title={Amygdala to nucleus accumbens excitatory transmission facilitates reward seeking},
  author={Garret D. Stuber and Dennis R. Sparta and Alice M Stamatakis and Wieke A. van Leeuwen and Juanita E. Hardjoprajitno and Saemi L. Cho and Kay M Tye and Kimberly A Kempadoo and Feng Zhang and Karl Deisseroth and Antonello Bonci},
The basolateral amygdala (BLA) has a crucial role in emotional learning irrespective of valence. The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction between these two brain regions has been limited by the inability to manipulate neural-circuit elements of this pathway selectively during behaviour. To circumvent this limitation, we used in vivo optogenetic stimulation or inhibition of glutamatergic… CONTINUE READING
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