Amygdala stimulation modulates hippocampal synaptic plasticity.

  title={Amygdala stimulation modulates hippocampal synaptic plasticity.},
  author={Kazuhito Nakao and Koji Matsuyama and Norio Matsuki and Yuji Ikegaya},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 39},
Experience-dependent synaptic plasticity is a fundamental feature of neural networks involved in the encoding of information, and the capability of synapses to express plasticity is itself activity-dependent. Here, we introduce a "low-frequency burst stimulation" protocol, which can readily induce both long-term potentiation (LTP) and long-term depression (LTD) at in vivo medial perforant path-dentate gyrus synapses. By varying stimulation parameters, we were able to build a stimulus-response… CONTINUE READING