Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

@article{Canli2005AmygdalaRI,
  title={Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation},
  author={T. Canli and E. Congdon and L. Gutknecht and R. T. Constable and K. Lesch},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={112},
  pages={1479-1485}
}
Summary.The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence. 
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