Amygdala kindling differentially regulates the expression of the elements involved in TRH transmission

  title={Amygdala kindling differentially regulates the expression of the elements involved in TRH transmission},
  author={Patricia de Gortari and Rosa Mar{\'i}a Uribe and Arlene I. Garc{\'i}a-V{\'a}zquez and Argel Aguilar-Valles and A. Mart{\'i}nez and Amanda Valdes and Jean-Louis Charli and Augusto Fern{\'a}ndez-Guardiola and Patricia Joseph-Bravo},
  journal={Neurochemistry International},

Stage-specific Modulation of Neprilysin and Aminopeptidase N in the Limbic System During Kindling Progression

Results demonstrate that expression of ectopeptidases can be regulated when peptide neurons are activated and, that regulation is enzyme-, region-, and stage-specific.

Analysis of the Stress Response in Rats Trained in the Water-Maze: Differential Expression of Corticotropin-Releasing Hormone, CRH-R1, Glucocorticoid Receptors and Brain-Derived Neurotrophic Factor in Limbic Regions

Results show that the Morris water-maze paradigm induces a strong stress response that is gradually attenuated, and inhibition of CRH expression in amygdala suggests that the stress inflicted is of physical but not of psychological nature and could lead to reduced fear or anxiety.



Region-specific changes in prodynorphin mRNA and ir-dynorphin A levels after kindled seizures

Data suggest that differential changes in dynorphin metabolism occur in different brain areas after seizures, and the mechanisms and functional implications of this observation remain to be investigated.

Activin mRNA induced during amygdala kindling shows a spatiotemporal progression that tracks the spread of seizures

The data suggest that activin and BDNF transcriptional activities accurately mark excitatory neurons participating in seizure‐induced synaptic alterations and may contribute to the enduring changes that underlie the kindled state.

Suckling and cold stress rapidly and transiently increase TRH mRNA in the paraventricular nucleus.

Results show a fast and transient response of TRH mRNA in PVN evoked by a neural stimulus in cold stimulated animals, consistent with its suggested role in thermogenesis.

Multifactorial Modulation of TRH Metabolism

Two combined approaches suggest that TRH action is modulated in a coordinate fashion: regulation of TRH biosynthesis and release as well as modulation of its inactivation by the target cell.