Amygdala interneuron subtypes control fear learning through disinhibition

@article{Wolff2014AmygdalaIS,
  title={Amygdala interneuron subtypes control fear learning through disinhibition},
  author={Steffen B. E. Wolff and Jan Gr{\"u}ndemann and Philip Tovote and Sabine Krabbe and Gilad A. Jacobson and Christian M{\"u}ller and Cyril Herry and I. P. Ehrlich S. C. Ehrlich I. P. Ehrlich and Rainer W. Friedrich and Johannes J. Letzkus and Andreas L{\"u}thi},
  journal={Nature},
  year={2014},
  volume={509},
  pages={453-458}
}
Learning is mediated by experience-dependent plasticity in neuronal circuits. Activity in neuronal circuits is tightly regulated by different subtypes of inhibitory interneurons, yet their role in learning is poorly understood. Using a combination of in vivo single-unit recordings and optogenetic manipulations, we show that in the mouse basolateral amygdala, interneurons expressing parvalbumin (PV) and somatostatin (SOM) bidirectionally control the acquisition of fear conditioning—a simple form… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 41 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 125 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

J. Neurosci

  • J. Neurosci
  • 2009

Similar Papers

Loading similar papers…