Amygdala interneuron subtypes control fear learning through disinhibition

  title={Amygdala interneuron subtypes control fear learning through disinhibition},
  author={Steffen B. E. Wolff and Jan Gr{\"u}ndemann and Philip Tovote and Sabine Krabbe and Gilad A. Jacobson and Christian M{\"u}ller and Cyril Herry and I. P. Ehrlich S. C. Ehrlich I. P. Ehrlich and Rainer W. Friedrich and Johannes J. Letzkus and Andreas L{\"u}thi},
Learning is mediated by experience-dependent plasticity in neuronal circuits. Activity in neuronal circuits is tightly regulated by different subtypes of inhibitory interneurons, yet their role in learning is poorly understood. Using a combination of in vivo single-unit recordings and optogenetic manipulations, we show that in the mouse basolateral amygdala, interneurons expressing parvalbumin (PV) and somatostatin (SOM) bidirectionally control the acquisition of fear conditioning—a simple form… CONTINUE READING
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J. Neurosci

  • J. Neurosci
  • 2009

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