Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation

@article{Donegan2003AmygdalaHI,
  title={Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation},
  author={Nelson H. Donegan and Charles A. Sanislow and Hilary P. Blumberg and Robert K. Fulbright and Cheryl Lacadie and Pawel Skudlarski and John C. Gore and Ingrid R. Olson and Thomas H. McGlashan and Bruce E. Wexler},
  journal={Biological Psychiatry},
  year={2003},
  volume={54},
  pages={1284-1293}
}
BACKGROUND Disturbed interpersonal relations and emotional dysregulation are fundamental aspects of borderline personality disorder (BPD). The amygdala plays important roles in modulating vigilance and generating negative emotional states and is often abnormally reactive in disorders of mood and emotion. The aim of this study was to assess amygdala reactivity in BPD patients relative to normal control subjects. We hypothesized that amygdala hyperreactivity contributes to hypervigilance… 
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