Amygdala, Medial Prefrontal Cortex, and Hippocampal Function in PTSD

  title={Amygdala, Medial Prefrontal Cortex, and Hippocampal Function in PTSD},
  author={Lisa M. Shin and Scott L. Rauch and Roger K Pitman},
  journal={Annals of the New York Academy of Sciences},
Abstract:  The last decade of neuroimaging research has yielded important information concerning the structure, neurochemistry, and function of the amygdala, medial prefrontal cortex, and hippocampus in posttraumatic stress disorder (PTSD). Neuroimaging research reviewed in this article reveals heightened amygdala responsivity in PTSD during symptomatic states and during the processing of trauma‐unrelated affective information. Importantly, amygdala responsivity is positively associated with… 

Voxel-based morphometric gray matter correlates of posttraumatic stress disorder.

Posttraumatic Stress Disorder: The Role of Medial Prefrontal Cortex and Amygdala

  • M. KoenigsJ. Grafman
  • Psychology, Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2009
Posttraumatic stress disorder (PTSD) is characterized by recurrent distressing memories of an emotionally traumatic event. In this review, the authors present neuroscientific data highlighting the

Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder.

Focal brain damage protects against post-traumatic stress disorder in combat veterans

A substantially reduced occurrence of PTSD is found among those individuals with damage to one of two regions of the brain: the vmPFC and an anterior temporal area that included the amygdala.

Frontal and subcortical grey matter reductions in PTSD

Aberrant Neural Connectivity During Emotional Processing Associated With Posttraumatic Stress

Analysis of patterns of functional connectivity among key brain regions implicated in the pathophysiology of posttraumatic stress disorder in 35 trauma-exposed adults using an emotion-word Stroop task suggests that hyperarousal is associated with negative mPFC-amygdala coupling and that reexperiencing isassociated with altered insula-hippocampus function, patterns of connectivity that may represent separable indicators of dysfunctional inhibitory control during affective processing.



Neural correlates of traumatic memories in posttraumatic stress disorder: a functional MRI investigation.

The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.

Brain activation in PTSD in response to trauma-related stimuli

Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD.

A reciprocal relationship between medial prefrontal cortex and amygdala function in PTSD and opposing associations between activity in these regions and symptom severity consistent with current functional neuroanatomic models of this disorder are suggested.